Use of Rituximab in child with SLE and myocardial involvement
نویسندگان
چکیده
Three years into diagnosis she had symptoms of increasing tiredness, breathlessness and tachycardia. An echocardiogram confirmed ventricular dilatation suggesting myocardial involvement. She was recommenced on Cyclophosphamide with Methyprednisolone, and was also commenced on Frusemide and Enalapril which initiated control of her cardiac function. Her ejection fraction improved from 30% to 52%. Subsequently, after 6 months of Cyclophosphamide, Rituximab was tried as sole agent which is currently holding her lupus and myocardial changes in control for over 20 months. She has had 3 cycles of Rituximab, each given at 1 gram/kg, divided in two doses two weeks apart. Her latest ejection fraction is 45%.
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